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KMID : 0377219840090010137
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Medical Journal of Chosun Univercity
1984 Volume.9 No. 1 p.137 ~ p.144
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studies on the Inhibitory Mechanism of Glucagon in Hepatic Fatty Acia Biosynthesis
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Abstract
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The rate of hepatic fatty acid synthesis measured by acetyl-CoA carboxylase, fatty acid synthetase activities and incorporation of tritium from ^(3)H_(2)O into fatty acids was decreased 60% within 15 minutes after injection with glucagon in rats. The hepatic acetyl-CoA carboxylase activity was decreased to one-third of control value, and the hepatic malonyl-CoA concentration was decreased to one-fourth of control value during the same period after glucagon injection. These data indicates that one site of action of glucagon in regulating fatty acid synthesis is at the acetyl-CoA carboxylase reaction. The hepatic long-chain aryl-CoA conceltration was not significantly different from the concentration in control at the time when the malonyl-CoA concentration reached a minimum value. The serum nonesterified fatty acid concentration increased repidly after glucagon injection, and reached a tnaXimum value at 5 minutes, followed by an increase in acetyl-CoA and ketone bodies and a decrease in the free mitochondrial 〔NAD^(+)〕/〔NADH〕 ratio.
The mechanism by which glucagon regulates fatty. acid biosynthesis must include a site of inhibition which decreases the acetyl-CoA carboxylase activity, the malonyl-CoA concentration and the fatty acid biosynthetic rate.
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